SYNTHESIS OF PROLINE AND 2-PIPERIDINECARBOXYLIC ACID VIA COBALT-CATALYZED ISOMERIZATION-CARBONYLATION OF N-ACYL UNSATURATED CYCLIC AMINES

被引：17

作者：

AMINO, Y ^{[1
]}

NISHI, S ^{[1
]}

IZAWA, K ^{[1
]}

机构：

[1] AJINOMOTO CO INC, CENT RES LAB, SUZUKI CHO, KAWASAKI KU, KAWASAKI, KANAGAWA 210, JAPAN

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1991年 / 64卷 / 02期

关键词：

D O I：

10.1246/bcsj.64.620

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-Acyl derivatives of proline and 2-piperidinecarboxylic acid (pipecolic acid) were synthesized in moderate yield from N-acyl unsaturated cyclic amines through cobalt-catalyzed isomerization-carboxylation under hydroformylation conditions in the presence of H2O. A possible mechanism for the process is discussed which is related to that of the amidocarbonylation (cobalt-catalyzed formation of N-acyl alpha-amino acid from aldehyde, amide and carbon monoxide).

引用

页码：620 / 623

页数：4

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