EFFECTS OF CYCLOSPORINE-A AND FK506 ON ISCHEMIA REPERFUSION-INDUCED NEUTROPHIL INFILTRATION IN THE CAT

被引：60

作者：

KUBES, P

HUNTER, J

GRANGER, DN

机构：

[1] Department of Physiology and Biophysics, Louisiana State University Medical Center, Shreveport, 71130, Louisiana

来源：

DIGESTIVE DISEASES AND SCIENCES | 1991年 / 36卷 / 10期

关键词：

FK506; CYCLOSPORINE-A; MYELOPEROXIDASE; LEUKOTRIENE-B4; NEUTROPHILS; LYMPHOCYTES;

D O I：

10.1007/BF01296817

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Isolated segments of cat small intestine were subjected to 3 hr of ischemia followed by 1 hr reperfusion (I/R). Mucosal biopsies were obtained for measurement of myeloperoxidase (MPO) activity, an index of tissue neutrophil count, and leukotriene B4 (LTB4) production. Animals were pretreated with either cyclosporin A (CsA) or FK506, which are potent immunosuppressants. Both agents significantly attenuated the neutrophil infiltration induced by I/R. FK506, but not CsA, reduced the elevated mucosal LTB4 production normally observed following reperfusion. The results of this study suggest that FK506 and CsA may be important agents in modulating neutrophil infiltration in acute inflammatory conditions.

引用

页码：1469 / 1472

页数：4

共 31 条

[1] PATTERNS OF LEUKOCYTE CHEMOTAXIS TO BILE AFTER LIVER-TRANSPLANTATION [J].

ADAMS, DH ;

BURNETT, D ;

STOCKLEY, RA ;

ELIAS, E .

GASTROENTEROLOGY, 1989, 97 (02) :433-438

[2]

BEVERIDGE T, 1981, CURR THER RES CLIN E, V30, P5

[3] BIOLOGICAL EFFECTS OF CYCLOSPORIN-A - NEW ANTILYMPHOCYTIC AGENT [J].

BOREL, JF ;

FEURER, C ;

GUBLER, HU ;

STAHELIN, H .

AGENTS AND ACTIONS, 1976, 6 (04) :468-475

[4] PLATELET-ACTIVATING-FACTOR AND CELLULAR IMMUNE-RESPONSES [J].

BRAQUET, P ;

ROLAPLESZCZYNSKI, M .

IMMUNOLOGY TODAY, 1987, 8 (11) :345-350

[5] CYCLOSPORIN-A MEDIATES IMMUNOSUPPRESSION OF PRIMARY CYTO-TOXIC T-CELL RESPONSES BY IMPAIRING THE RELEASE OF INTERLEUKIN-1 AND INTERLEUKIN-2 [J].

BUNJES, D ;

HARDT, C ;

ROLLINGHOFF, M ;

WAGNER, H .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1981, 11 (08) :657-661

[6] SMALL BOWEL TRANSPLANTATION IN THE DOG USING CYCLOSPORINE [J].

CRADDOCK, GN ;

NORDGREN, SR ;

REZNICK, RK ;

GILAS, T ;

LOSSING, AG ;

COHEN, Z ;

STILLER, CR ;

CULLEN, JB ;

LANGER, B .

TRANSPLANTATION, 1983, 35 (04) :284-288

[7] LEUKOTRIENE-B, A POTENT CHEMOKINETIC AND AGGREGATING SUBSTANCE RELEASED FROM POLYMORPHONUCLEAR LEUKOCYTES [J].

FORDHUTCHINSON, AW ;

BRAY, MA ;

DOIG, MV ;

SHIPLEY, ME ;

SMITH, MJH .

NATURE, 1980, 286 (5770) :264-265

[8]

GRANGER DN, 1981, GASTROENTEROLOGY, V81, P22

[9] SUCCESSFUL INTESTINAL TRANSPLANTATION IN PIGS TREATED WITH CYCLOSPORINE [J].

GRANT, D ;

DUFF, J ;

ZHONG, R ;

GARCIA, B ;

LIPOHAR, C ;

KEOWN, P ;

STILLER, C .

TRANSPLANTATION, 1988, 45 (02) :279-284

[10]

GRANT D, 1989, TRANSPLANT P, V21, P2869

← 1 2 3 4 →