MITOCHONDRIAL DAMAGE BY ACTIVE OXYGEN SPECIES INVITRO

被引：40

作者：

MEHROTRA, S ^{[1
]}

KAKKAR, P ^{[1
]}

VISWANATHAN, PN ^{[1
]}

机构：

[1] IND TOXICOL RES CTR,ECOTOXICOL SECT,POST BOX 80,MG MARG,LUCKNOW 226001,UTTAR PRADESH,INDIA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1991年 / 10卷 / 05期

关键词：

FREE RADICALS; MITOCHONDRIA; LIPID PEROXIDATION; MEMBRANE DAMAGE; CALCIUM DYNAMICS;

D O I：

10.1016/0891-5849(91)90034-Z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Under in vitro conditions involving formation of active oxygen species, rat liver mitochondria were found to undergo swelling, peroxidative decomposition of lipids, and distinct disorganization of ultrastructure. Supplementation with free radical scavengers such as superoxide dismutase (SOD), methionine, histidine, and tryptophan accorded considerable protection to the organelle. A possible correlation between oxygen radicals, membrane integrity, and calcium functions is indicated.

引用

页码：277 / 285

页数：9

共 27 条

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