DIRECT SYNTHESIS OF BOC PROTECTED (D,L)-AMINO ACIDS FROM BOC-GLYCINE

被引：7

作者：

DENICOLA, A ^{[1
]}

EINHORN, J ^{[1
]}

LUCHE, JL ^{[1
]}

机构：

[1] UNIV J FOURIER,ETUD DYNAM & STRUCT SELECT LAB,BATIMENT CHIM,BP 53X,F-38041 GRENOBLE,FRANCE

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 43期

关键词：

TRIANION; LITHIUM DIISOPROPYLAMIDE; TERT-BUTOXYCARBONYL; ALKYLATION; AMINO ACID;

D O I：

10.1016/S0040-4039(00)79015-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Boc-glycine is easily deprotonated by lithium diisopropylamide, yielding a trianion which is trapped with an electrophile to give access to Boc-(DL)-amino acids.

引用

页码：6461 / 6464

页数：4

共 6 条

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[4] KRAPCHO AP, 1976, TETRAHEDRON LETT, V17, P2205
[5] ON THE INTERACTION BETWEEN LITHIUM ENOLATES AND SECONDARY-AMINES IN SOLUTION AND IN THE CRYSTAL
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[J]. HELVETICA CHIMICA ACTA, 1985, 68 (05) : 1373 - 1393
[6] ALPHA ANIONS OF CARBOXYLIC-ACIDS .2. FORMATION AND ALKYLATION OF ALPHA-METALATED ALIPHATIC ACIDS
PFEFFER, PE
SILBERT, LS
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[J]. JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (03) : 451 - &

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