OSTEOGENIC RESPONSE TO POROUS HYDROXYAPATITE CERAMICS UNDER THE SKIN OF DOGS

被引：223

作者：

YAMASAKI, H ^{[1
]}

SAKAI, H ^{[1
]}

机构：

[1] KYUSHU UNIV, FAC DENT, DEPT ORAL PATHOL, HIGASHI KU, FUKUOKA 812, JAPAN

来源：

BIOMATERIALS | 1992年 / 13卷 / 05期

关键词：

HYDROXYAPATITE; MICROSTRUCTURE OSTEOGENESIS; TISSUE REACTION;

D O I：

10.1016/0142-9612(92)90054-R

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Soft tissue reactions to two materials of different microstructure made with porous and dense hydroxyapatite ceramic granules, were compared in this study. Each was implanted subcutaneously in the abdomen of 10 dogs. The implants were removed 1, 3 and 6 months after implantation, and examined by light microscopy. Heterotopic bone formation was only evident around porous hydroxyapatite ceramic granules in 6 of the 10 animals after 3 months, and in all cases after 6 months, but never around dense granules. These findings suggested that cellular differentiation and induction of osteogenesis may be influenced by the physical and chemical factors in the micromilieu provided by porous hydroxyapatite ceramic granules.

引用

页码：308 / 312

页数：5

共 26 条

[1] LONG-TERM RADIOGRAPHIC EVALUATION OF HYDROXYLAPATITE-AUGMENTED MANDIBULAR ALVEOLAR RIDGES [J].

BLOCK, MS ;

KENT, JN .

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 1984, 42 (12) :793-796

[2]

BUCHOLZ RW, 1987, ORTHOP CLIN N AM, V18, P323

[3] TISSUE-RESPONSE TO DENSE APATITE IMPLANTS IN RATS [J].

DENISSEN, HW ;

DEGROOT, K ;

MAKKES, PC ;

VANDENHOOFF, A ;

KLOPPER, PJ .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1980, 14 (06) :713-721

[4] IMMEDIATE DENTAL ROOT IMPLANTS FROM SYNTHETIC DENSE CALCIUM HYDROXYLAPATITE [J].

DENISSEN, HW ;

DEGROOT, K .

JOURNAL OF PROSTHETIC DENTISTRY, 1979, 42 (05) :551-556

[5] A HISTOLOGIC EVALUATION OF A MANDIBULAR CROSS-SECTION ONE YEAR AFTER AUGMENTATION WITH HYDROXYAPATITE PARTICLES [J].

DONATH, K ;

ROHRER, MD ;

BECKMANNAGETTA, J .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 1987, 63 (06) :651-655

[6] HISTOLOGIC OBSERVATION OF SOFT-TISSUE RESPONSES TO IMPLANTED, MULTIFACETED PARTICLES AND DISKS OF HYDROXYLAPATITE [J].

DROBECK, HP ;

ROTHSTEIN, SS ;

GUMAER, KI ;

SHERER, AD ;

SLIGHTER, RG .

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 1984, 42 (03) :143-149

[7]

ELDEEB M, 1989, J ORAL MAXIL SURG, V47, P50

[8] TISSUE-RESPONSE IN DOGS TO DENSE HYDROXYLAPATITE IMPLANTATION IN THE FEMUR [J].

GUMAER, KI ;

SHERER, AD ;

SLIGHTER, RG ;

ROTHSTEIN, SS ;

DROBECK, HP .

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 1986, 44 (08) :618-627

[9] EVALUATION OF A SUBCUTANEOUSLY IMPLANTED HYDROXYLAPATITE-AVITENE MIXTURE IN RABBITS [J].

HARVEY, WK ;

PINCOCK, JL ;

MATUKAS, VJ ;

LEMONS, JE .

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 1985, 43 (04) :277-280

[10] PHYSICOCHEMICAL CHARACTERIZATION OF DEPOSITS ASSOCIATED WITH HA CERAMICS IMPLANTED IN NONOSSEOUS SITES [J].

HEUGHEBAERT, M ;

LEGEROS, RZ ;

GINESTE, M ;

GUILHEM, A ;

BONEL, G .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH-APPLIED BIOMATERIALS, 1988, 22 (A3) :257-268

← 1 2 3 →