ANTIOXIDATIVE ACTIVITY OF SYNTHETIC MELANINS - CARDIOLIPIN LIPOSOME MODEL

被引:49
作者
POREBSKABUDNY, M [1 ]
SAKINA, NL [1 ]
STEPIEN, KB [1 ]
DONTSOV, AE [1 ]
WILCZOK, T [1 ]
机构
[1] ACAD SCI USSR,INST CHEM PHYS,MOSCOW V-71,USSR
关键词
CATECHOLAMINE-MELANIN; DOPA-MELANIN; ANTIOXIDANT; CARDIOLIPIN; LIPID PEROXIDATION; MELANIN;
D O I
10.1016/0304-4165(92)90121-A
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The inhibiting effect of melanin synthesized from dihydroxyphenylalanine (DOPA), dopamine, adrenaline and adrenolutin on the ultraviolet- or the Fe2+-ascorbic acid-induced peroxidation of cardiolipin liposomes has been studied. All these melanins are able to inhibit both the ultraviolet- and the Fe2+-ascorbic acid-induced lipid peroxidation. Antioxidative activity of melanins enhances in the order: dopamine-melanin < melanin synthesized from dopamine in the presence of Cu2+ < DOPA - melanin < melanin synthesized from adrenaline in the presence of Cu2+ congruent-to adrenolutin-melanin, and correlates with their ability to scavenge superoxide anion radical. The optical screening effect of the investigated melanins in the inhibition of lipid peroxidation was not higher than 15% for the most active melanins.
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页码:11 / 16
页数:6
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