INHIBITION OF THE GROWTH OF INFLUENZA-VIRUSES IN-VITRO BY 4-GUANIDINO-2,4-DIDEOXY-N-ACETYLNEURAMINIC ACID

被引：40

作者：

THOMAS, GP ^{[1
]}

FORSYTH, M ^{[1
]}

PENN, CR ^{[1
]}

MCCAULEY, JW ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,DEPT VIROL,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

ANTIVIRAL RESEARCH | 1994年 / 24卷 / 04期

关键词：

4-GUANIDINO-NEU5AC2EN; INFLUENZA; SIALIDASE; NEURAMINIDASE;

D O I：

10.1016/0166-3542(94)90081-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The sialidase inhibitor 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid was tested for growth inhibitory effects against a panel of avian influenza A viruses encompassing all nine neuraminidase subtypes. Growth in tissue culture of viruses from each subtype was inhibited by this compound at concentrations within a range previously found effective against human N1 and N2 viruses. This compound may prove a selective agent for the treatment (and prevention) of influenza virus infections.

引用

页码：351 / 356

页数：6

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