ANTINEOPLASTIC AGENTS .315. ISOLATION AND STRUCTURE OF THE MARINE SPONGE CANCER CELL-GROWTH INHIBITOR PHAKELLISTATIN-5

被引：31

作者：

PETTIT, GR

XU, JP

CICHACZ, ZA

WILLIAMS, MD

DORSAZ, AC

BRUNE, DC

BOYD, MR

CERNY, RL

机构：

[1] ARIZONA STATE UNIV, DEPT CHEM, TEMPE, AZ 85287 USA

[2] NCI, FREDERICK CANC RES & DEV CTR, DIV CANC TREATMENT, DEV THERAPEUT PROGRAM, FREDERICK, MD 21702 USA

[3] UNIV NEBRASKA, DEPT CHEM, MIDWEST CTR MASS SPECT, LINCOLN, NE 68588 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(01)80108-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The Federated State of Micronesia (Chuuk) marine sponge Phakellia costada has been found to contain (9.6 x 10(-6) % yield) a new human cancer cell growth inhibitor designated phakellistatin 5 (3). Structural elucidation was accomplished employing high resolution FAB tandem MS/MS and high field (500 MHz) 2D-NMR techniques. Extension of the NMR experiments over the temperature range -25 to 25 degrees C allowed the principal solution conformation of phakellistatin 5 to be assigned (Figure 2). The absolute configuration was found to correspond to S-amino acid units except for R-Asn.

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页码：2091 / 2096

页数：6

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