EFFECTS OF N-SUBSTITUTION ON THE ACTIVATION MECHANISMS OF 4-HYDROXYCYCLOPHOSPHAMIDE ANALOGS

被引：10

作者：

KWON, CH

BORCH, RF

机构：

[1] UNIV ROCHESTER,DEPT PHARMACOL,ROCHESTER,NY 14642

[2] UNIV ROCHESTER,CTR CANC,ROCHESTER,NY 14642

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1989年 / 32卷 / 07期

关键词：

D O I：

10.1021/jm00127a016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1491 / 1496

页数：6

共 33 条

[1]

ALLEN LM, 1972, CANCER CHEMOTH REP 1, V56, P603

[2] ENZYMATIC TOXICOGENATION OF ACTIVATED CYCLOPHOSPHAMIDE BY 3'-5' EXONUCLEASES [J].

BIELICKI, L ;

VOELCKER, G ;

HOHORST, HJ .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1983, 105 (01) :27-29

[3]

BIELICKI L, 1984, J CANCER RES CLIN, V187, P195

[4] INSITU PREPARATION AND FATE OF CIS-4-HYDROXYCYCLOPHOSPHAMIDE AND ALDOPHOSPHAMIDE - H-1 AND P-31 NMR EVIDENCE FOR EQUILIBRATION OF CIS-4--HYDROXYCYCLOPHOSPHAMIDE AND TRANS-4-HYDROXYCYCLOPHOSPHAMIDE WITH ALDOPHOSPHAMIDE AND ITS HYDRATE IN AQUEOUS-SOLUTION [J].

BORCH, RF ;

HOYE, TR ;

SWANSON, TA .

JOURNAL OF MEDICINAL CHEMISTRY, 1984, 27 (04) :490-494

[5] THE MECHANISM OF ACTIVATION OF 4-HYDROXYCYCLOPHOSPHAMIDE [J].

BORCH, RF ;

MILLARD, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (02) :427-431

[6] IFOSFAMIDE - PHARMACOLOGY, SAFETY AND THERAPEUTIC POTENTIAL [J].

BRADE, WP ;

HERDRICH, K ;

VARINI, M .

CANCER TREATMENT REVIEWS, 1985, 12 (01) :1-47

[7] CYCLOPHOSPHAMIDE VERSUS IFOSFAMIDE - FINAL REPORT OF A RANDOMIZED PHASE-II TRIAL IN ADULT SOFT-TISSUE SARCOMAS [J].

BRAMWELL, VHC ;

MOURIDSEN, HT ;

SANTORO, A ;

BLACKLEDGE, G ;

SOMERS, R ;

VERWEY, J ;

DOMBERNOWSKY, P ;

ONSRUD, M ;

THOMAS, D ;

SYLVESTER, R ;

VANOOSTEROM, A .

EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1987, 23 (03) :311-321

[8]

BRYANT BM, 1980, LANCET, V2, P657

[9]

CACECI MS, 1984, BYTE, V9, P340

[10]

CHU MY, 1968, BIOCHEM PHARMACOL, V17, P753

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