SPECIFICITY OF GENTAMICIN ACCUMULATION BY RAT RENAL CORTEX

被引：16

作者：

KUO, CH

HOOK, JB

机构：

[1] Department of Pharmacology, Toxicology Michigan State University East Lansing

来源：

LIFE SCIENCES | 1979年 / 25卷 / 10期

关键词：

D O I：

10.1016/0024-3205(79)90545-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The accumulation of gentamicin by rat renal cortex in vivo and in vitro was not inhibited by probenecid, tetraethylammonium, cephalosporins nor α-aminoisobutyric acid, but was significantly blocked by other aminoglycosides (neomycin, tobramycin and kanamycin). The data suggest that specific binding sites for aminoglycosides are present on the surface or in cells of the renal proximal tubule. © 1979.

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页码：873 / 878

页数：6

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