FREQUENCY AND VOLTAGE DEPENDENT EFFECTS OF AN-132, A NEW CLASS-I ANTI-ARRHYTHMIC AGENT, ON VMAX OF ACTION-POTENTIAL UPSTROKE IN GUINEA-PIG VENTRICULAR MUSCLES

被引:6
作者
CHIHARA, S
KODAMA, I
TOYAMA, J
机构
[1] NAGOYA UNIV,ENVIRONM MED RES INST,DEPT CIRCULAT & RESP,FURO CHO,CHIKUSA KU,NAGOYA,AICHI 464,JAPAN
[2] CHUGAI PHARMACEUT CO LTD,NEW DRUG RES LABS,TOKYO 171,JAPAN
关键词
D O I
10.1093/cvr/22.9.648
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:648 / 655
页数:8
相关论文
共 18 条
[1]   KINETICS OF ONSET OF RATE-DEPENDENT EFFECTS OF CLASS-I ANTI-ARRHYTHMIC DRUGS ARE IMPORTANT IN DETERMINING THEIR EFFECTS ON REFRACTORINESS IN GUINEA-PIG VENTRICLE, AND PROVIDE A THEORETICAL BASIS FOR THEIR SUBCLASSIFICATION [J].
CAMPBELL, TJ .
CARDIOVASCULAR RESEARCH, 1983, 17 (06) :344-352
[2]   IMPORTANCE OF PHYSICOCHEMICAL PROPERTIES IN DETERMINING THE KINETICS OF THE EFFECTS OF CLASS-I ANTI-ARRHYTHMIC DRUGS ON MAXIMUM RATE OF DEPOLARIZATION IN GUINEA-PIG VENTRICLE [J].
CAMPBELL, TJ .
BRITISH JOURNAL OF PHARMACOLOGY, 1983, 80 (01) :33-40
[3]  
CAMPBELL TJ, 1980, J CARDIOVASC PHARM, V12, P1273
[4]  
CARMELIET E, 1979, HDB PHYSL CARDIOVASC, V1, P269
[8]   THE INFLUENCE OF MOLECULAR-FORM OF LOCAL ANESTHETIC-TYPE ANTI-ARRHYTHMIC AGENTS ON REDUCTION OF THE MAXIMUM UPSTROKE VELOCITY OF CANINE CARDIAC PURKINJE-FIBERS [J].
GINTANT, GA ;
HOFFMAN, BF ;
NAYLOR, RE .
CIRCULATION RESEARCH, 1983, 52 (06) :735-746
[9]   ANTIARRHYTHMIC DRUG-ACTION - BLOCKADE OF THE INWARD SODIUM CURRENT [J].
GRANT, AO ;
STARMER, CF ;
STRAUSS, HC .
CIRCULATION RESEARCH, 1984, 55 (04) :427-439
[10]   TEST OF A MODEL OF ANTI-ARRHYTHMIC DRUG-ACTION - EFFECTS OF QUINIDINE AND LIDOCAINE ON MYOCARDIAL CONDUCTION [J].
HONDEGHEM, L ;
KATZUNG, BG .
CIRCULATION, 1980, 61 (06) :1217-1224