CURRENT-VOLTAGE RELATIONSHIP OF THE BASOLATERAL MEMBRANE OF A TIGHT EPITHELIUM

被引：36

作者：

WILLS, NK ^{[1
]}

EATON, DC ^{[1
]}

LEWIS, SA ^{[1
]}

IFSHIN, MS ^{[1
]}

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT PHYSIOL & BIOPHYS,GALVESTON,TX 77550

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 555卷 / 03期

关键词：

(Rabbit colon); Basolateral membrane; Current-voltage relationship; Nystatin;

D O I：

10.1016/0005-2736(79)90405-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The polyene antibiotic nystatin is used to reduce selectively to zero the apical membrane resistance of the rabbit descending colon, allowing the measurement of the current-voltage curve of the basolateral membrane. The I-V relationship is described by the Goldman-Hodgkin-Katz equations allowing calculation of PNa/PK, PCl/PK and PK for the basolateral membrane. Cs+ is found to block inward current (serosa → mucosa) in a manner similar to that found in excitable membranes. © 1979.

引用

页码：519 / 523

页数：5

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