BLOOD-BRAIN-BARRIER - MECHANISMS OF PEPTIDE REGULATION AND TRANSPORT

被引：9

作者：

AUDUS, KL

机构：

[1] Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence

来源：

JOURNAL OF CONTROLLED RELEASE | 1990年 / 11卷 / 1-3期

关键词：

aminopeptidase; angiotensin; blood-brain barrier; endocytosis; peptide transport; sleep-inducing peptide;

D O I：

10.1016/0168-3659(90)90120-I

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Delivery of peptide and protein drugs to the central nervous system from the blood is subject to the permeability limitations imposed by the blood-brain barrier. Recent development of an in vitro model permits the opportunity to explore fundamental blood-brain barrier characteristics at the cellular and biochemical level. In part, information generated from such studies will be necessary to develop strategies for delivering blood-borne therapeutic peptide and proteins across the blood-brain barrier to central nervous system sites of action. Reviewed here are applications of the in vitro model in studies of the biochemistry of both peptide regulation of transcellular vesicular pathways and transmembrane transport of peptides. © 1990.

引用

页码：51 / 59

页数：9

共 33 条

[1] Bradbury, The blood-brain barrier: Transport across the cerebral endothelium, Circ. Res., 57, pp. 213-222, (1985)
[2] Cornford, The blood-brain barrier, a dynamic regulatory interface, Mol. Physiol., 7, pp. 219-260, (1985)
[3] Cervos-Navarro, Kannuki, Nakagawa, Blood-brain barrier (BBB): Review from morphological aspect, Histol. Histopathol., 3, pp. 203-213, (1988)
[4] Joo, The blood-brain barrier in vitro: Ten years of research on microvessels isolated from the brain, Neurochem. Int., 7, pp. 1-25, (1985)
[5] Audus, Borchardt, Characterization of an in vitro blood-brain barrier model system for studying drug transport and metabolism, Pharm. Res., 3, pp. 81-87, (1986)
[6] Audus, Borchardt, Bovine brain microvessel endothelial cell monolayers as a model system for the blood-brain barrier, Annals of the New York Academy of Sciences, 507, pp. 9-18, (1987)
[7] Grubb, Raichle, Intraventricular angiotensin II increases brain vascular permeability, Brain Res., 210, pp. 426-430, (1981)
[8] Baba, Oishi, Saeki, Enhancement of blood-brain barrier permeability to sodium fluorescein by stimulation β opioid receptors in mice, Naunyn-Schmiedeberg's Arch. Pharmacol., 337, pp. 423-428, (1988)
[9] Wahl, Unterberg, Baethmann, Schilling, Mediators of blood-brain barrier dysfunction and formation of vasogenic edema, J. Cerebr. Blood Flow Metab., 8, pp. 621-643, (1988)
[10] Banks, Kastin, Interactions between the blood-brain barrier and endogenous peptides Emerging clinical implications, The American Journal of the Medical Sciences, 31, pp. 459-465, (1988)

← 1 2 3 4 →