TRICHINELLA-SPIRALIS - IMMUNITY AND INFLAMMATION IN THE EXPULSION OF TRANSPLANTED ADULT WORMS FROM MICE

The technique of implanting adult Trichinella spiralis into the intestines of mice has been used to assess the contributions of direct, anti-worm immunity and of intestinal inflammation to worm expulsion. The survival after transfer of worms exposed to an effective adoptive immunity in donors was no different from that of worms taken from control donors. Worms taken from donors 8 days after infection, i.e., shortly before the onset of expulsion, showed no increased susceptibility to an immunity adoptively transferred to the recipient mice. When worms were implanted into mice responding to a prior, oral infection they were expelled rapidly. This expulsion was independent of the age of the worms transferred and took place at the same time as the expulsion of the existing infection. © 1979.