CEREBRAL VASOSPASM AND VASOCONSTRICTION CAUSED BY ENDOTHELIN

被引:97
作者
KOBAYASHI, H [1 ]
HAYASHI, M [1 ]
KOBAYASHI, S [1 ]
KABUTO, M [1 ]
HANDA, Y [1 ]
KAWANO, H [1 ]
IDE, H [1 ]
机构
[1] TOYAMA MED & PHARMACEUT UNIV,DEPT CHEM PHARMACOL,SUGITANI,TOYAMA 93001,JAPAN
关键词
CEREBRAL VASOSPASM; ENDOTHELIAL CELL; ENDOTHELIN-1; VASOCONSTRICTION;
D O I
10.1227/00006123-199105000-00006
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We investigated the histological changes between arteries constricted by endothelin for 7 days and vasospastic arteries induced by the double injection of autologous blood. Group 1 was a sham-operated group. Group 2 animals received a continuous cisternal injection of endothelin-1 (1.7 x 10-9 mol/7 days) by a miniosmotic pump implanted in the neck musculature for 7 days. Group 3 received double injections of cisternal blood administered 48 hours apart. Angiography showed severe constriction of the basilar artery, 34.6% and 43% in Groups 2 and 3, respectively, on Day 7. Histological study showed marked constriction of the basilar artery in both Group 2 and Group 3. Degenerative changes in endothelial cells and smooth muscle cells were observed in both Group 2 and Group 3. Immunohistochemical study demonstrated endothelin-1 in the endothelial cells in Group 2, but not in Group 1 or in Group 3. It is suggested that endothelin-1 may play an important role in the pathogenesis of cerebral vasospasm.
引用
收藏
页码:673 / 679
页数:7
相关论文
共 28 条
  • [1] ENDOTHELIN AND THE PRODUCTION OF CEREBRAL VASOSPASM IN DOGS
    ASANO, T
    IKEGAKI, I
    SUZUKI, Y
    SATOH, S
    SHIBUYA, M
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 159 (03) : 1345 - 1351
  • [2] ENDOTHELIN INDUCES POTENT MICROVASCULAR CONSTRICTION
    BRAIN, SD
    TIPPINS, JR
    WILLIAMS, TJ
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1988, 95 (04) : 1005 - 1007
  • [3] PATHOGENESIS OF CEREBRAL INFARCTION FOLLOWING RUPTURE OF CEREBRAL BERRY ANEURYSMS
    CROMPTON, MR
    [J]. BRAIN, 1964, 87 (03) : 491 - &
  • [4] PHARMACOLOGY OF ENDOTHELIN-1 IN ISOLATED VESSELS - EFFECT OF NICARDIPINE, METHYLENE-BLUE, HEMOGLOBIN, AND GOSSYPOL
    DORLEANSJUSTE, P
    FINET, M
    DENUCCI, G
    VANE, JR
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1989, 13 : S19 - S22
  • [5] PROGRESS IN CEREBROVASCULAR-DISEASE - MANAGEMENT OF CEREBRAL ANEURYSM
    DRAKE, CG
    [J]. STROKE, 1981, 12 (03) : 273 - 283
  • [6] CELLULAR MECHANISM OF ACTION BY A NOVEL VASOCONSTRICTOR ENDOTHELIN IN CULTURED RAT VASCULAR SMOOTH-MUSCLE CELLS
    HIRATA, Y
    YOSHIMI, H
    TAKATA, S
    WATANABE, TX
    KUMAGAI, S
    NAKAJIMA, K
    SAKAKIBARA, S
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 154 (03) : 868 - 875
  • [7] IDE K, 1989, Neurological Research, V11, P101
  • [8] THE HUMAN ENDOTHELIN FAMILY - 3 STRUCTURALLY AND PHARMACOLOGICALLY DISTINCT ISOPEPTIDES PREDICTED BY 3 SEPARATE GENES
    INOUE, A
    YANAGISAWA, M
    KIMURA, S
    KASUYA, Y
    MIYAUCHI, T
    GOTO, K
    MASAKI, T
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) : 2863 - 2867
  • [9] CEREBRAL VASOSPASM FOLLOWING ANEURYSMAL SUBARACHNOID HEMORRHAGE
    KASSELL, NF
    SASAKI, T
    COLOHAN, ART
    NAZAR, G
    [J]. STROKE, 1985, 16 (04) : 562 - 572
  • [10] EFFECT OF ENDOTHELIN ON THE CANINE BASILAR ARTERY
    KOBAYASHI, H
    HAYASHI, M
    KOBAYASHI, S
    KABUTO, M
    HANDA, Y
    KAWANO, H
    [J]. NEUROSURGERY, 1990, 27 (03) : 357 - 361