D-OPTIMAL DESIGNS FOR A MULTIVARIATE REGRESSION-MODEL

Considered is a linear regression model with a one-dimensional control variable and an m-dimensional response variable y. The components of y may be correlated with known covariance matrix. Let B be the covariance matrix of the Gauss-Markoff estimator for the unknown parameter vector of the model. Under rather mild assumptions on the set of regression functions a factorization lemma for det B is proved which implies that D-optimal designs do not depend on the covariance matrix of y. This allows the use of recent results of Dette to determine approximate D-optimal designs for polynomial regression. A partial result for exact D-optimal designs is given too. © 1992.