THERMOANALYTICAL AND SPECTRAL STUDY OF BENZODIAZEPINES .2. NORDAZEPAM

被引：7

作者：

CHAUVET, A ^{[1
]}

ELMOUSSAOUI, A ^{[1
]}

MASSE, J ^{[1
]}

机构：

[1] FAC PHARM MONTPELLIER,CHIM GEN & MINERALE LAB,AVE CHARLES FLAHAUT,F-34060 MONTPELLIER,FRANCE

来源：

THERMOCHIMICA ACTA | 1992年 / 210卷

关键词：

D O I：

10.1016/0040-6031(92)80283-3

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Continuing our investigation of the thermal and spectral behaviour of benzodiazepines we have studied nordazepam. After crystallization in various solvents at different temperatures the samples show thermal and spectral behaviour which allows us to characterize the polymorphism and pseudopolymorphism of nordazepam. We have obtained form I after transition at 213.0 +/- 0.5-degrees-C (T(f) = 221.3 +/- 0.6-degrees-C: DELTAH = 24.45 +/- 0.75 kJ mol-1), form II (T(f) = 216.7 +/- 0.4-degrees-C; DELTAH = 34.00 +/- 0.49 kJ mol-1) form III (T(f) = 216.0 +/- 0.6-degrees-C; DELTAH = 27.40 +/- 0.58 kJ mol-1) form IV (T(f) = 214.2 +/- 0.3-degrees-C; DELTAH = 33.62 +/- 0.40 kJ mol-1) and a solvate (5-1) nordazepam-dioxane.

引用

页码：133 / 145

页数：13

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