FC-EPSILON RECEPTOR MEDIATED CA2+ INFLUX INTO MAST-CELLS IS MODULATED BY THE CONCENTRATION OF CYTOSOLIC FREE CA2+ IONS

被引:24
作者
DAR, O [1 ]
PECHT, I [1 ]
机构
[1] WEIZMANN INST SCI,DEPT CHEM IMMUNOL,IL-76100 REHOVOT,ISRAEL
关键词
MAST CELL; RAT BASOPHILIC LEUKEMIA CELL (RBL-2H3); TYPE-1 FC-EPSILON RECEPTOR; CA2+ INFLUX; SIGNAL TRANSDUCTION; THAPSIGARGIN;
D O I
10.1016/0014-5793(92)81311-9
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The relationship between the Fc-epsilon receptor mediated stimulation of mast cells and the Ca2+ signal it induces were studied using thapsigargin (TG), a blocker of the endoplasmic reticulum Ca2+ pump. TG induced. in mucosal mast cells (RBL-2H3 line), a dose-dependent and an InsP3-independent increase in [Ca2+]i (from resting levels of 83-150 nM to 600-680 nM), and a secretory response amounting to 30-50% of that observed upon Fc-epsilon-RI clustering. The TG induced rise of [Ca2+]i is most probably provided by both arrest of its uptake by the endoplasmic reticulum and influx from the medium. Thus, Ca2+ influx in mast cells may be modulated by the [Ca2+]i level.
引用
收藏
页码:123 / 128
页数:6
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