COMPARATIVE DISSOLUTION CHARACTERISTICS OF BROPIRIMINE-BETA-CYCLODEXTRIN INCLUSION COMPLEX AND ITS SOLID DISPERSION WITH PEG-6000

An inclusion complex of bropirimine (ABPP) with beta-cyclodextrin (betaCD) and its solid dispersion with polyethylene glycol 6000 (PEG 6000) were prepared by the coprecipitation method. Comparative dissolution studies revealed that the solid complex exhibited a markedly faster dissolution rate compared to the PEG 6000 solid dispersions and physical mixtures in water and phosphate buffer (pH 7.4). However, the dissolution of all the test preparations was enhanced to almost the same extent in 0.1 N HCI. H-1-NMR was employed to confirm the inclusion of the drug within the beta-CD cavity. The high solubility and instant release of the drug were maintained upon ageing of the solid complex for 1 year, while the release of the solid dispersions decreased. TLC investigations proved that this decrease in the release rate was not due to drug degradation.