SEIZURE AFTER FLUMAZENIL ADMINISTRATION IN A PEDIATRIC-PATIENT

被引:12
作者
MCDUFFEE, AT
TOBIAS, JD
机构
[1] Department of Pediatrics, Division of Pediatric Critical Care and Anesthesia, Vanderbilt University Medical Center, Nashville, TN
关键词
FLUMAZENIL; SEIZURE;
D O I
10.1097/00006565-199506000-00013
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Flumazenil is a benzodiazepine receptor antagonist used to reverse sedation and respiratory depression induced by benzodiazepines. Seizures and cardiac arrhythmias have complicated its use in adult patients, Overdose patients who have coingested tricyclic antidepressants have a higher risk of these complications. Little information exists concerning adverse effects of flumazenil in children. We report the occurrence of a generalized tonic-clonic seizure in a pediatric patient following the administration of flumazenil.
引用
收藏
页码:186 / 187
页数:2
相关论文
共 12 条
[1]  
Sugarman J.M., Paul R.I., Flumazenil: A review, Pediatr Emerg Care, 10, pp. 37-43, (1994)
[2]  
Longmire A.W., Seger D.L., Topics in clinical pharmacology: Flumazenil, a benzodiazepine antagonist, Am J Med Sci, 306, pp. 49-52, (1993)
[3]  
Spivey W.H., Flumazenil and seizures: Analysis of 43 cases, Clin Ther, 14, pp. 292-305, (1992)
[4]  
Mordel A., Winkler E., Almog S., Seizures after flumazenil administration in a case of combined benzodiazepine and tricyclic antidepressant overdose, Crit Care Med, 20, pp. 1733-1734, (1992)
[5]  
Marchant B., Wray R., Leach A., Flumazenil causing convulsions and ventricular tachycardia, Br Med J, 299, (1989)
[6]  
Burr W., Sandham P., Judd A., Death after flumazenil, Br Med J, 298, (1989)
[7]  
O'Connor H.J., Status epilepticus following administration of flumazenil after endoscopy, Endoscopy, 23, (1991)
[8]  
Jones R., Lawson A.D., Rew L.J., Et al., Antagonism of the hypnotic effect of midazolam in children: A randomized, double-blind study of placebo and flumazenil administered after midazolam-induced anaesthesia, Br J Anaesth, 66, pp. 660-666, (1991)
[9]  
Lopez A., Rebollo J., Benzodiazepine withdrawal syndrome after a benzodiazepine antagonist, Crit Care Med, 18, pp. 1480-1481, (1990)
[10]  
Roald O.K., Dahl V., Flunitrazepam intoxication in a child successfully treated with the benzodiazepine antagonist flumazenil, Crit Care Med, 17, pp. 1355-1356, (1989)