FROM THE DARK ZONE TO THE LIGHT

被引：30

作者：

MACLENNAN, ICM

机构：

[1] Department of Immunology, University of Birmingham Medical School, Birmingham

来源：

CURRENT BIOLOGY | 1994年 / 4卷 / 01期

关键词：

D O I：

10.1016/S0960-9822(00)00017-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The affinity maturation of antibodies that occurs during immune responses to protein antigens involves site-directed hypermutation of immunogoblin variable-region genes that is activated in germinal centres. © 1994 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：70 / 72

页数：3

相关论文

共 13 条

[1] MOLECULAR EVENTS DURING MATURATION OF THE IMMUNE-RESPONSE TO OXAZOLONE [J].

BEREK, C ;

GRIFFITHS, GM ;

MILSTEIN, C .

NATURE, 1985, 316 (6027) :412-418

[2] MATURATION OF THE IMMUNE-RESPONSE IN GERMINAL-CENTERS [J].

BEREK, C ;

BERGER, A ;

APEL, M .

CELL, 1991, 67 (06) :1121-1129

[3] VIRGIN B-CELL RECRUITMENT AND THE LIFE-SPAN OF MEMORY CLONES DURING ANTIBODY-RESPONSES TO 2,4-DINITROPHENYL-HEMOCYANIN [J].

GRAY, D ;

MACLENNAN, ICM ;

LANE, PJL .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1986, 16 (06) :641-648

[4] QUANTITATIVE-ANALYSIS OF MOLECULES WHICH DISTINGUISH FUNCTIONAL COMPARTMENTS WITHIN GERMINAL-CENTERS [J].

HARDIE, DL ;

JOHNSON, GD ;

KHAN, M ;

MACLENNAN, ICM .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1993, 23 (05) :997-1004

[5] INTRACLONAL GENERATION OF ANTIBODY MUTANTS IN GERMINAL-CENTERS [J].

JACOB, J ;

KELSOE, G ;

RAJEWSKY, K ;

WEISS, U .

NATURE, 1991, 354 (6352) :389-392

[6] INSITU STUDIES OF THE PRIMARY IMMUNE-RESPONSE TO (4-HYDROXY-3-NITROPHENYL)ACETYL .2. A COMMON CLONAL ORIGIN FOR PERIARTERIOLAR LYMPHOID SHEATH-ASSOCIATED FOCI AND GERMINAL-CENTERS [J].

JACOB, J ;

KELSOE, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (03) :679-687

[7] ANALYSIS OF SOMATIC MUTATION ACTIVITY IN MULTIPLE V(KAPPA) GENES INVOLVED IN THE RESPONSE TO 2-PHENYL-5-OXAZOLONE [J].

KALLBERG, E ;

GRAY, D ;

LEANDERSON, T .

INTERNATIONAL IMMUNOLOGY, 1993, 5 (06) :573-581

[8] GERMINAL-CENTERS DEVELOP OLIGOCLONALLY [J].

KROESE, FGM ;

WUBBENA, AS ;

SEIJEN, HG ;

NIEUWENHUIS, P .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (07) :1069-1072

[9] TRACING B-CELL DEVELOPMENT IN HUMAN GERMINAL-CENTERS BY MOLECULAR ANALYSIS OF SINGLE CELLS PICKED FROM HISTOLOGICAL SECTIONS [J].

KUPPERS, R ;

ZHAO, M ;

HANSMANN, ML ;

RAJEWSKY, K .

EMBO JOURNAL, 1993, 12 (13) :4955-4967

[10] MECHANISM OF ANTIGEN-DRIVEN SELECTION IN GERMINAL-CENTERS [J].

LIU, YJ ;

JOSHUA, DE ;

WILLIAMS, GT ;

SMITH, CA ;

GORDON, J ;

MACLENNAN, ICM .

NATURE, 1989, 342 (6252) :929-931