MUTAGENICITY IN YEAST OF NITROQUINOLINES AND RELATED COMPOUNDS

被引：20

作者：

EPSTEIN, SS

STPIERRE, JA

机构：

[1] Laboratory of Environmental Toxicology, Children's Cancer Research Foundation, Inc., Boston

[2] Laboratory of Carcinogenesis, Children's Cancer Research Foundation, Inc., Boston

[3] the Department of Pathology, Harvard Medical School, Boston, MA

[4] Department of Biology, Boston College, Chestnut Hill, MA

来源：

TOXICOLOGY AND APPLIED PHARMACOLOGY | 1969年 / 15卷 / 02期

关键词：

D O I：

10.1016/0041-008X(69)90043-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of 14 nitroquinolines and hydroxyaminoquinolines, related to the potent water-soluble carcinogen 4-nitroquinoline 1-oxide (4-NQO), were tested for induction of respiratory-deficient mutants in Saccharomyces cerevisiae. Eight quinolines, including 4-NQO and 4-hydroxyaminoquinoline 1-oxide, were mutagenic at concentrations markedly inhibiting growth; remaining compounds were nonmutagenic. Good correlation was demonstrated between mutagenicity of these quinolines and established data on their carcinogenicity, photodynamic activity, free-radical production, and lysogeny. © 1969.

引用

页码：451 / &

共 25 条

[1] IN VIVO DIFFERENTIATION OF YEAST CYTOPLASMIC AND MITOCHONDRIAL PROTEIN SYNTHESIS WITH ANTIBIOTICS [J].