HYDRAZINES AS MUTAGENS IN A HISTIDINE-REQUIRING AUXOTROPH OF SALMONELLA-TYPHIMURIUM

被引：51

作者：

TOSK, J

SCHMELTZ, I

HOFFMANN, D

机构：

[1] American Health Foundation, Naylor Dana Institute for Disease Prevention, Valhalla

来源：

MUTATION RESEARCH | 1979年 / 66卷 / 03期

关键词：

D O I：

10.1016/0165-1218(79)90085-5

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Hydrazines have been found naturally in tobacco and mushrooms. Other hydrazines are used in industry, medicine, and agriculture. Although about 38 hydrazines are carcinogenic, few, if any, have been tested successfully in rapid bacterial mutagenesis assays. We have utilized a tester strain of Salmonella typhimurium (TA1530) in order to determine the mutagenic activity of a number of hydrazines and related compounds. This strain is thus shown to be effective as a tester organism for the facile detection of hydrazines as mutagens. © 1979.

引用

页码：247 / 252

页数：6

共 13 条

[1] Ames B.N., 1971, CHEMICAL MUTAGENS PR, P267
[2] IMPROVED BACTERIAL TEST SYSTEM FOR DETECTION AND CLASSIFICATION OF MUTAGENS AND CARCINOGENS
AMES, BN
LEE, FD
DURSTON, WE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) : 782 - 786
[3] BRUSICK DJ, 1977, 7TH P ANN C ENV TOX, P108
[4] METABOLIC FATE OF HYDRAZINES AND HYDRAZIDES
COLVIN, LB
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1969, 58 (12) : 1433 - &
[5] HEPATOCARCINOGENICITY OF HERBICIDE MALEIC HYDRAZIDE FOLLOWING PARENTERAL ADMINISTRATION TO INFANT SWISS MICE
EPSTEIN, SS
MANTEL, N
[J]. INTERNATIONAL JOURNAL OF CANCER, 1968, 3 (03) : 325 - &
[6] MUTAGENICITY OF HYDRAZINE AND SOME OF ITS DERIVATIVES
KIMBALL, RF
[J]. MUTATION RESEARCH, 1977, 39 (02): : 111 - 126
[7] CHEMICAL STUDIES ON TOBACCO-SMOKE - QUANTITATIVE-ANALYSIS OF HYDRAZINE IN TOBACCO AND CIGARETTE-SMOKE
LIU, YY
SCHMELTZ, I
HOFFMANN, D
[J]. ANALYTICAL CHEMISTRY, 1974, 46 (07) : 885 - 889
[8] MITCHELL JR, 1975, CLIN PHARMACOL THER, V18, P70
[9] NAGEL D, 1977, CANCER RES, V37, P3458
[10] CHEMICAL STUDIES ON TOBACCO-SMOKE .48. TUMORIGENIC AGENTS IN UNBURNED PROCESSED TOBACCO - N-NITROSODIETHANOLAMINE AND 1,1-DIMETHYLHYDRAZINE
SCHMELTZ, I
ABIDI, S
HOFFMANN, D
[J]. CANCER LETTERS, 1977, 2 (03) : 125 - 131

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