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UP-REGULATION OF THE INTESTINAL 1,25-DIHYDROXYVITAMIN-D RECEPTOR DURING HYPERVITAMINOSIS-D - A COMPARISON BETWEEN VITAMIN-D2 AND VITAMIN-D3

被引：15
作者：
BECKMAN, MJ
HORST, RL
REINHARDT, TA
BEITZ, DC
机构：
[1] USDA ARS, NATL ANIM DIS CTR, AMES, IA 50010 USA
[2] IOWA STATE UNIV SCI & TECHNOL, DEPT ANIM SCI, AMES, IA 50011 USA
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 169卷 / 03期
关键词：
D O I：
10.1016/0006-291X(90)91979-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Concentrations of intestinal 1,25-dihydroxyvitamin D receptor were measured in rats receiving pharmacological amounts (25,000 IU/rat daily for 6 days) of either vitamin D2 or vitamin D3. The data showed that both hypervitaminosis D2 and hypervitaminosis D3 resulted in significant up-regulation of intestinal 1,25-dihydroxyvitamin D receptor (fmol/mg protein) relative to controls (409 ± 24, vitamin D2-treated; 525 ± 41, vitamin D3-treated; and 249 ± 19, control). The 1,25-dihydroxyvitamin D receptor enhancement also was accompanied by elevated plasma 25-hydroxyvitamin D and hypercalcemia. These data suggest that increased target-tissue 1,25-dihydroxyvitamin D receptor may play a role in enhancing target tissue responsiveness and, thus, have a significant role in mediating the toxic effects of hypervitaminosis D. © 1990.
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页码：910 / 915
页数：6
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