THE REDUCTION OF CHROMATE IS A PREREQUISITE OF CHROMIUM BINDING TO CELL-NUCLEI

被引：35

作者：

KORTENKAMP, A ^{[1
]}

OBRIEN, P ^{[1
]}

BEYERSMANN, D ^{[1
]}

机构：

[1] UNIV BREMEN, DEPT BIOL & CHEM, W-2800 BREMEN 33, GERMANY

来源：

CARCINOGENESIS | 1991年 / 12卷 / 06期

关键词：

D O I：

10.1093/carcin/12.6.1143

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Isolated calf thymus nuclei bound a chromium(III) glutathione complex in a time-dependent manner. In contrast chromium(VI) (sodium chromate) did not bind. However, when chromate was incubated with the nuclei in the presence of glutathione, chromium adducts were detected. These observations indicate that the reduction of chromate, by a reducing agent such as glutathione, is a prerequisite for the generation of bonds between the metal and constituents of the cell nuclei in vitro. Chromium adducts with nuclei are probably one cause of DNA lesions and mutations.

引用

页码：1143 / 1144

页数：2

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