DENERVATION OF DOPAMINERGIC-NEURONS WITH 6-HYDROXYDOPAMINE INCREASES NERVE GROWTH-FACTOR CONTENT IN RAT-BRAIN

被引：50

作者：

NITTA, A

FURUKAWA, Y

HAYASHI, K

HIRAMATSU, M

KAMEYAMA, T

HASEGAWA, T

NABESHIMA, T

机构：

[1] NAGOYA UNIV,SCH MED,DEPT NEUROPSYCHOPHARMACOL & HOSP PHARM,SYOWA KU,NAGOYA,AICHI 466,JAPAN

[2] GIFU PHARMACEUT UNIV,DEPT MOLEC BIOL,GIFU 502,JAPAN

[3] MEIJO UNIV,FAC PHARMACEUT SCI,DEPT CHEM PHARMACOL,NAGOYA,AICHI 468,JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 144卷 / 1-2期

关键词：

NERVE GROWTH FACTOR; DOPAMINERGIC DENERVATION; 6-HYDROXYDOPAMINE; CORTEX; HIPPOCAMPUS; RAT;

D O I：

10.1016/0304-3940(92)90738-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5--28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.

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页码：152 / 156

页数：5

相关论文

共 33 条

[1] REDUCTION OF STRIATAL DOPAMINERGIC NEUROTRANSMISSION ELEVATES STRIATAL PROENKEPHALIN MESSENGER-RNA [J].

ANGULO, JA ;

DAVIS, LG ;

BURKHART, BA ;

CHRISTOPH, GR .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1986, 130 (03) :341-343

[2] NERVE GROWTH-FACTOR (NGF) POTENTIATES THE CHANGES IN STRIATAL PROENKEPHALIN MESSENGER-RNAS SUBSEQUENT TO 6-HYDROXYDOPAMINE-INDUCED LESIONS OF THE SUBSTANTIA-NIGRA [J].

CADET, JL ;

ANGULO, JA ;

MCEWEN, BS .

BRAIN RESEARCH BULLETIN, 1990, 25 (03) :401-405

[3] PROLONGED AND SELECTIVE INDUCTION OF FOS-RELATED ANTIGEN(S) IN STRIATAL NEURONS AFTER 6-HYDROXYDOPAMINE LESIONS OF THE RAT SUBSTANTIA-NIGRA PARS COMPACTA [J].

DRAGUNOW, M ;

LEAH, JD ;

FAULL, RLM .

MOLECULAR BRAIN RESEARCH, 1991, 10 (04) :355-358

[4] TIME COURSE OF THE CHANGES IN STRIATAL ACETYLCHOLINE LEVELS INDUCED BY PERGOLIDE AND HALOPERIDOL AFTER LESION OF THE NIGROSTRIATAL DOPAMINERGIC PATHWAYS IN THE RAT [J].

FAGE, D ;

GUERIN, B ;

FEUERSTEIN, C ;

DEMENGE, P ;

SCATTON, B .

BRAIN RESEARCH, 1984, 310 (02) :379-383

[5] A HIGHLY SENSITIVE ENZYME-IMMUNOASSAY FOR MOUSE BETA-NERVE GROWTH-FACTOR [J].

FURUKAWA, S ;

KAMO, I ;

FURUKAWA, Y ;

AKAZAWA, S ;

SATOYOSHI, E ;

ITOH, K ;

HAYASHI, K .

JOURNAL OF NEUROCHEMISTRY, 1983, 40 (03) :734-744

[6] REGULATION OF NERVE GROWTH-FACTOR SYNTHESIS SECRETION BY CATECHOLAMINE IN CULTURED MOUSE ASTROGLIAL CELLS [J].

FURUKAWA, S ;

FURUKAWA, Y ;

SATOYOSHI, E ;

HAYASHI, K .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 147 (03) :1048-1054

[7] TIME COURSE OF THE ELEVATION OF NERVE GROWTH-FACTOR (NGF) CONTENT IN THE HIPPOCAMPUS AND SEPTUM FOLLOWING LESIONS OF THE SEPTOHIPPOCAMPAL PATHWAY IN RATS [J].

GASSER, UE ;

WESKAMP, G ;

OTTEN, U ;

DRAVID, AR .

BRAIN RESEARCH, 1986, 376 (02) :351-356

[8]

GNAHN H, 1983, DEV BRAIN RES, V9, P45, DOI 10.1016/0165-3806(83)90107-4

[9] NERVE GROWTH-FACTOR INCREASES CHOLINE ACETYL-TRANSFERASE BUT NOT SURVIVAL OR FIBER OUTGROWTH OF CULTURED FETAL SEPTAL CHOLINERGIC NEURONS [J].

HEFTI, F ;

HARTIKKA, J ;

ECKENSTEIN, F ;

GNAHN, H ;

HEUMANN, R ;

SCHWAB, M .

NEUROSCIENCE, 1985, 14 (01) :55-68

[10]

HEFTI F, 1986, J NEUROSCI, V6, P2155

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