SYNAPTOTAGMIN - A CALCIUM SENSOR ON THE SYNAPTIC VESICLE SURFACE

被引：812

作者：

BROSE, N

PETRENKO, AG

SUDHOF, TC

JAHN, R

机构：

[1] MAX PLANCK INST PSYCHIAT,DEPT NEUROCHEM,W-8033 MARTINSRIED,GERMANY

[2] UNIV TEXAS,SW MED CTR,HOWARD HUGHES MED INST,DALLAS,TX 75235

[3] UNIV TEXAS,SW MED CTR,DEPT MOLEC GENET,DALLAS,TX 75235

来源：

SCIENCE | 1992年 / 256卷 / 5059期

关键词：

D O I：

10.1126/science.1589771

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neurons release neurotransmitters by calcium-dependent exocytosis of synaptic vesicles. However, the molecular steps transducing the calcium signal into membrane fusion are still an enigma. It is reported here that synaptotagmin, a highly conserved synaptic vesicle protein, binds calcium at physiological concentrations in a complex with negatively charged phospholipids. This binding is specific for calcium and involves the cytoplasmic domain of synaptotagmin. Calcium binding is dependent on the intact oligomeric structure of synaptotagmin (it is abolished by proteolytic cleavage at a single site). These results suggest that synaptotagmin acts as a cooperative calcium receptor in exocytosis.

引用

页码：1021 / 1025

页数：5

共 27 条

[1] CALCIUM ACTION IN SYNAPTIC TRANSMITTER RELEASE [J].