EFFECTS OF GRANISETRON AND HALOPERIDOL, ALONE AND IN COMBINATION, ON PSYCHOMETRIC PERFORMANCE AND THE EEG

1 The effects of granisetron (160-mu-g kg-1 body weight) and haloperidol (3 mg) on psychometric performance and the EEG were investigated in a randomised, single-blind, crossover, placebo controlled study of 12 healthy male volunteers. 2 There was evidence that haloperidol impaired psychometric performance; however its effects on the EEG were not clear cut. In contrast there was very little evidence to suggest that granisetron had any impact on performance or the EEG. 3 The findings from this study suggest that granisetron does not impair daytime function and that it can be co-administered with haloperidol without producing unwanted synergistic effects.