ROLE OF RENIN-ANGIOTENSIN SYSTEM IN BLOOD-PRESSURE REGULATION IN PREGNANCY

被引：32

作者：

AUGUST, P ^{[1
]}

MUELLER, FB ^{[1
]}

SEALEY, JE ^{[1
]}

EDERSHEIM, TG ^{[1
]}

机构：

[1] CORNELL UNIV,MED CTR,NEW YORK HOSP,CTR CARDIOVASC,DEPT OBSTET & GYNECOL,NEW YORK,NY 10021

来源：

LANCET | 1995年 / 345卷 / 8954期

关键词：

D O I：

10.1016/S0140-6736(95)90012-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We gave captopril (25 mg) to nine pregnant and eight nonpregnant women. From baseline to 60 min post-captopril, mean arterial pressure decreased significantly more in pregnant than in non-pregnant women (mean 15.0 [SE 25] vs 5.2 [1.2] mm Hg; difference 9.8 [95% CI 3.9-1.59] mm Hg, p=0.0036), whereas plasma renin activity increased significantly more in the pregnant group (18.0 [5.5] vs 4.5 [1.9] ng mL(-1) h(-1); difference 13.5 [0.71-26.5], p=0.043). These findings support the hypothesis that stimulation of the renin-angiotensin system in pregnancy maintains blood pressure.

引用

页码：896 / 897

页数：2

共 10 条

[1] LONGITUDINAL-STUDY OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM IN HYPERTENSIVE PREGNANT-WOMEN - DEVIATIONS RELATED TO THE DEVELOPMENT OF SUPERIMPOSED PREECLAMPSIA [J].

AUGUST, P ;

LENZ, T ;

ALES, KL ;

DRUZIN, ML ;

EDERSHEIM, TG ;

HUTSON, JM ;

MULLER, FB ;

LARAGH, JH ;

SEALEY, JE .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 163 (05) :1612-1621

[2]

HANSSENS M, 1991, OBSTET GYNECOL, V78, P128

[3]

LARAGH JH, 1992, HDB RENAL PHYSL, P1409

[4] PRORENIN SECRETION FROM HUMAN PLACENTA PERFUSED INVITRO [J].

LENZ, T ;

JAMES, GD ;

LARAGH, JH ;

SEALEY, JE .

AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (06) :E876-E882

[5]

LINDHEIMER MD, 1992, KIDNEY PHYSL PATHOPH, P3371

[6] MAINTENANCE OF BLOOD-PRESSURE BY THE RENIN-ANGIOTENSIN SYSTEM IN NORMAL MAN [J].

MACGREGOR, GA ;

MARKANDU, ND ;

ROULSTON, JE ;

JONES, JC ;

MORTON, JJ .

NATURE, 1981, 291 (5813) :329-331

[7] THE CAPTOPRIL TEST FOR IDENTIFYING RENOVASCULAR DISEASE IN HYPERTENSIVE PATIENTS [J].

MULLER, FB ;

SEALEY, JE ;

CASE, DB ;

ATLAS, SA ;

PICKERING, TG ;

PECKER, MS ;

PREIBISZ, JJ ;

LARAGH, JH .

AMERICAN JOURNAL OF MEDICINE, 1986, 80 (04) :633-644

[8]

SCHRIER RW, 1991, OBSTET GYNECOL, V77, P632

[9]

SEALEY JE, 1991, CLIN CHEM, V37, P1811

[10]

Skinner SL, 1993, RENIN ANGIOTENSIN SY, V1

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