BETA-ETHOXYVINYL POLYFLUOROALKYL KETONES - VERSATILE SYNTHONES IN FLUOROORGANIC CHEMISTRY

被引：67

作者：

GERUS, II ^{[1
]}

GORBUNOVA, MG ^{[1
]}

KUKHAR, VP ^{[1
]}

机构：

[1] UKRAINIAN ACAD SCI,INST BIOORGAN & PETROCHEM,KIEV 253660,UKRAINE

来源：

JOURNAL OF FLUORINE CHEMISTRY | 1994年 / 69卷 / 03期

关键词：

BETA-ETHOXYVINYL POLYFLUOROALKYL KETONES; SYNTHONES; PROTECTING GROUP; PEPTIDE SYNTHESIS; REACTIONS;

D O I：

10.1016/0022-1139(94)03130-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

We have found readily available beta-ethoxyvinyl trifluoromethyl ketone to be a convenient and comprehensive starting material for the synthesis of various fluoro-containing compounds such as heterocycles, enones, enaminones and chelate complexes. The 4,4,4-trifluoro-3-oxo-1-butenyl group formed by beta-ethoxyvinyl trifluoromethyl ketone is a suitable protecting group for the N-H terminal of amino acids in peptide synthesis. The formation of peptides using these protected amino acids occurs without racemization.

引用

页码：195 / 198

页数：4

共 11 条

[1]

Gambaryan N.P., 1967, IAN SSSR KH, P918

[2]

GERUS II, 1990, ZH ORG KHIM+, V26, P1877

[3]

GERUS II, UNPUB

[4]

GERUS II, 1991, KHIM GETEROTS SOEDIN, V4, P502

[5]

GERUS II, 1993, UKR KHIM ZH, V59, P408

[6] THE INTERACTION OF 4-ETHOXY-1,1,1-TRIFLUORO-3-BUTEN-2-ONE WITH C-NUCLEOPHILES - ORGANO-MAGNESIUM AND ORGANO-ZINC COMPOUNDS [J].

GORBUNOVA, MG ;

GERUS, II ;

KUKHAR, VP .

JOURNAL OF FLUORINE CHEMISTRY, 1993, 65 (1-2) :25-28

[7]

GORBUNOVA MG, 1991, SYNTHESIS-STUTTGART, P207

[8] ELECTROPHILIC SUBSTITUTIONS OF OLEFINIC HYDROGENS .2. ACYLATION OF VINYL ETHERS AND N-VINYL AMIDES [J].

HOJO, M ;

MASUDA, R ;

KOKURYO, Y ;

SHIODA, H ;

MATSUO, S .

CHEMISTRY LETTERS, 1976, (05) :499-502

[9]

KUKHAR VP, 1991, DOKL AKAD NAUK UKR, V2, P129

[10]

TISCHENKO MA, 1989, UKR KHIM ZH, V55, P1195

← 1 2 →