LOD SCORE METHOD FOR DETECTING LINKAGE ON THE X-CHROMOSOME BETWEEN A MARKER LOCUS AND A MAJOR GENE LOCUS FOR A QUANTITATIVE CHARACTER

被引：3

作者：

BOCK, RD

PERLINE, R

机构：

[1] Department of Behavioral Sciences, The University of Chicago, Chicago, 60637, Illinois

来源：

BEHAVIOR GENETICS | 1979年 / 9卷 / 03期

关键词：

linkage; lod score; major gene; marker locus; quantitative character; X chromosome;

D O I：

10.1007/BF01071297

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

A sequential lod-score method is proposed for detecting linkage on the X chromosome between a marker locus and the locus of a major gene influencing a quantitative trait. The method uses information from sons of doubly heterozygous mothers. The average number of families required to detect linkage is substantially less than that of the fixed sample-size method proposed by Hill. © 1979 Plenum Publishing Corporation.

引用

页码：139 / 149

页数：11

共 17 条

[1]

BOCK RD, 1973, AM J HUM GENET, V25, P1

[2]

BOCK RD, 1977, APPLICATIONS STATIST, P89

[3]

DAY NE, 1969, BIOMETRIKA, V56, P463, DOI 10.1093/biomet/56.3.463

[4] GENERAL MODEL FOR GENETIC ANALYSIS OF PEDIGREE DATA [J].