MICROWAVE SYSTEM FOR THE CONTROLLED PRODUCTION OF LOCAL TUMOR HYPERTHERMIA IN ANIMALS

A microwave system was designed and constructed which provides controlled localized hyperthermia in the tumors of four experimental animals. The components of the system are a 2.45-GHz microwave source, a four-way power-dividing network and reflected power monitor, a temperature-controlled microwave power regulator, and small direct-contact microwave applicators. Adjustment of the temperature control results in elevated temperatures in the centers of tumors which can be maintained to within ± 0.1 °C without production of significant whole body hyperthermia. The temperatures at the edges of the locally heated tumors were found to vary within ± 1.0°C of the center temperature. The system is currently being used to evaluate the therapeutic potential of sustained localized hyperthermia in small tumors implanted subcutaneously in mice. Copyright © 1979 by The Institute of Electrical and Electronics Engineers, Inc.