1-(DICHLOROACETYL)-1,2,3,4-TETRAHYDRO-6-QUINOLINOL ESTERS - NEW POTENT ANTI-AMEBIC AGENTS

被引：21

作者：

BAILEY, DM ^{[1
]}

MOUNT, EM ^{[1
]}

SIGGINS, J ^{[1
]}

CARLSON, JA ^{[1
]}

YARINSKY, A ^{[1
]}

SLIGHTER, RG ^{[1
]}

机构：

[1] STERLING WINTHROP RES INST,DEPT PARASITOL,RENSSELAER,NY 12144

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1979年 / 22卷 / 05期

关键词：

D O I：

10.1021/jm00191a031

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1-(dichloroacetyl)-1, 2, 3, 4-tetrahydro-6-quinolinols and certain O-acyl derivatives thereof have been prepared and shown to be potent antiamebic agents in the Entamoeba criceti infected hamster model. Compounds were compared with etichlordifene and diloxamide and one of them, 1-(dichloroacetyl)-6-(2-furoyloxy)-1, 2, 3, 4-tetrahydroquinoline (4), was selected for human trial. © 1979, American Chemical Society. All rights reserved.

引用

页码：599 / 601

页数：3