SUPPRESSION OF RENIN SECRETION IN THE RAT-KIDNEY BY A NONVASCULAR ALPHA-ADRENERGIC MECHANISM

被引：54

作者：

VANDONGEN, R ^{[1
]}

STRANG, KD ^{[1
]}

POESSE, MH ^{[1
]}

BIRKENHAGER, WH ^{[1
]}

机构：

[1] ZUIDERZIEKENHUIS, DEPT INTERNAL MED, ROTTERDAM, NETHERLANDS

来源：

CIRCULATION RESEARCH | 1979年 / 45卷 / 04期

关键词：

D O I：

10.1161/01.RES.45.4.435

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The authors studied the effect of α-adrenergic stimulation, using phenylephrine, on basal and isoproterenol-provoked renin secretion in the isolated perfused rat kidney. Infusion of phenylephrine increased renal perfusion pressure and prevented the response in renin secretion to isoproterenol. No suppression of basal secretion was observed. Renal vasoconstriction was abolished, and the response in renin secretion to isoproterenol was restored by α-adrenoceptor blockade with phenoxybenzamine. In contrast, when renal vasoconstriction was prevented by dihydralazine, suppression of renin release by phenylephrine still occurred. These observations support an inhibitory effect of a nonvascular α-adrenergic mechanism on renin release. The authors suggest that the α receptor mediating this effect is related directly to the juxtaglomerular cell.

引用

页码：435 / 439

页数：5

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