HYPOGLYCEMIC EFFECTS OF SESQUITERPENE GLYCOSIDES AND POLYHYDROXYLATED TRITERPENOIDS OF ERIOBOTRYA-JAPONICA

被引：88

作者：

DETOMMASI, N

DESIMONE, F

CIRINO, G

CICALA, C

PIZZA, C

机构：

[1] UNIV NAPOLI FEDERICO 2, DIPARTIMENTO CHIM SOSTANZE NAT, VIA D MONTESANO 49, I-80131 NAPLES, ITALY

[2] UNIV NAPOLI FEDERICO 2, DIPARTIMENTO FARMACOL SPERIMENTALE, I-80131 NAPLES, ITALY

来源：

PLANTA MEDICA | 1991年 / 57卷 / 05期

关键词：

ERIOBOTRYA-JAPONICA; HYPOGLYCEMIC EFFECTS; SESQUITERPENE GLYCOSIDES; POLYHYDROXYLATED TRITERPENOIDS;

D O I：

10.1055/s-2006-960137

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effects of the constituent sesquiterpene glycosides 1-3 and polyhydroxylated triterpenoids 5-6 isolated by MeOH extraction of Eriobotrya japonica were studied in genetically diabetic mice (C57BL/KS-db/db/Ola) and normoglycemic rats. The sesquiterpene glycoside 3 and the polyhydroxylated triterpenoids 5 and 6 produced a marked inhibition of glycosuria. Furthermore, 5 and 6 were able to reduce blood glucose levels in normoglycemic rats. While there are already some data reported on hypoglycemic activity of polyhydroxylated triterpenoids, there are no previous data showing hypoglycemic activity of sesquiterpene glycosides.

引用

页码：414 / 416

页数：3

共 9 条

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