THE SHORTEST SYNTHESIS OF OPTICALLY-ACTIVE GEISSMAN-WAISS LACTONE, A KEY SYNTHETIC INTERMEDIATE FOR NECINE BASES

被引：32

作者：

TAKAHATA, H

BANBA, Y

MOMOSE, T

机构：

[1] Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, 930-01

来源：

TETRAHEDRON-ASYMMETRY | 1991年 / 2卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(00)82169-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A short synthesis of (+)-(1R,5R)-2-oxa-6-azabicyclo[3.3.0]octan-3-one (the Geissman-Waiss lactone, 1) by palladium (II)-catalyzed intramolecular aminocarbonylation of (R)-N-benzyloxycarbonyl-3-hydroxy-4-pentenylamine (4) available from the Katsuki-Sharpless kinetic resolution of racemic 4 has been accomplished.

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页码：445 / 448

页数：4

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