INHIBITION OF GLUTAMATE RELEASE IN RAT HIPPOCAMPUS BY KYNURENIC ACID DOES NOT PROTECT CA1 CELLS FROM FOREBRAIN ISCHEMIA

被引：19

作者：

LEKIEFFRE, D ^{[1
]}

GHRIBI, O ^{[1
]}

CALLEBERT, J ^{[1
]}

ALLIX, M ^{[1
]}

PLOTKINE, M ^{[1
]}

BOULU, RG ^{[1
]}

机构：

[1] UNIV PARIS 05,FAC SCI PHARMACEUT & BIOL,PHARMACOL LAB,4 AVE OBSERV,F-75270 PARIS 06,FRANCE

来源：

BRAIN RESEARCH | 1992年 / 592卷 / 1-2期

关键词：

HIPPOCAMPUS; MICRODIALYSIS; GLUTAMATE; NEURONAL DEATH; FOREBRAIN ISCHEMIA; RAT; KYNURENIC ACID;

D O I：

10.1016/0006-8993(92)91693-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We assessed the effect of a broad spectrum glutamatergic receptor antagonist, kynurenic acid (500 mg/k ) on ischemia-induced hippocampal glutamate release and neuronal damage. Kynurenic acid significantly decreased glutamate release during ischemia but had no effect on the hippocampal lesion. Some protection was observed in the cortex and in the striatum. These data suggested that the extracellular accumulation of glutamate during forebrain ischemia does not play a major role in the hippocampus.

引用

页码：333 / 337

页数：5

共 39 条

[1] THE EXCITATORY AMINO-ACID ANTAGONIST KYNURENIC ACID ADMINISTERED AFTER HYPOXIC-ISCHEMIA IN NEONATAL RATS OFFERS NEUROPROTECTION
ANDINE, P
LEHMANN, A
ELLREN, K
WENNBERG, E
KJELLMER, I
NIELSEN, T
HAGBERG, H
[J]. NEUROSCIENCE LETTERS, 1988, 90 (1-2) : 208 - 212
[2] GYKI-52466 BLOCKS THE INCREASE IN EXTRACELLULAR GLUTAMATE INDUCED BY ISCHEMIA
ARVIN, B
MONCADA, C
LEPEILLET, E
CHAPMAN, A
MELDRUM, BS
[J]. NEUROREPORT, 1992, 3 (03) : 235 - 238
[3] ELEVATION OF THE EXTRACELLULAR CONCENTRATIONS OF GLUTAMATE AND ASPARTATE IN RAT HIPPOCAMPUS DURING TRANSIENT CEREBRAL-ISCHEMIA MONITORED BY INTRACEREBRAL MICRODIALYSIS
BENVENISTE, H
DREJER, J
SCHOUSBOE, A
DIEMER, NH
[J]. JOURNAL OF NEUROCHEMISTRY, 1984, 43 (05) : 1369 - 1374
[4] KYNURENIC ACID ANTAGONISES RESPONSES TO NMDA VIA AN ACTION AT THE STRYCHNINE-INSENSITIVE GLYCINE RECEPTOR
BIRCH, PJ
GROSSMAN, CJ
HAYES, AG
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 154 (01) : 85 - 87
[5] KYNURENATE AND FG9041 HAVE BOTH COMPETITIVE AND NON-COMPETITIVE ANTAGONIST ACTIONS AT EXCITATORY AMINO-ACID RECEPTORS
BIRCH, PJ
GROSSMAN, CJ
HAYES, AG
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 151 (02) : 313 - 315
[6] BLOCK GA, 1987, CEREBROVASC DIS, P37
[7] BUCHAN A, 1991, J NEUROSCI, V11, P1049
[8] BUCHAN AM, 1990, CEREBROVAS BRAIN MET, V2, P1
[9] BLOCKADE OF THE AMPA RECEPTOR PREVENTS CA1 HIPPOCAMPAL INJURY FOLLOWING SEVERE BUT TRANSIENT FOREBRAIN ISCHEMIA IN ADULT-RATS
BUCHAN, AM
LI, H
CHO, S
PULSINELLI, WA
[J]. NEUROSCIENCE LETTERS, 1991, 132 (02) : 255 - 258
[10] THE NONCOMPETITIVE NMDA-RECEPTOR ANTAGONIST MK-801 PREVENTS THE MASSIVE RELEASE OF GLUTAMATE AND ASPARTATE FROM RAT STRIATUM INDUCED BY 1-METHYL-4-PHENYLPYRIDINIUM (MPP+)
CARBONI, S
MELIS, F
PANI, L
HADJICONSTANTINOU, M
ROSSETTI, ZL
[J]. NEUROSCIENCE LETTERS, 1990, 117 (1-2) : 129 - 133

← 1 2 3 4 →