ADENOSINE INHIBITS THE NMDA RECEPTOR-MEDIATED EXCITATORY POSTSYNAPTIC POTENTIAL IN THE HIPPOCAMPUS

被引：54

作者：

DEMENDONCA, A ^{[1
]}

RIBEIRO, JA ^{[1
]}

机构：

[1] HOSP SANTA MARIA,CTR ESTUDOS EGAS MONIZ,LISBON,PORTUGAL

来源：

BRAIN RESEARCH | 1993年 / 606卷 / 02期

关键词：

ADENOSINE; 2-CHLOROADENOSINE; LONG-TERM POTENTIATION; GLUTAMATE; N-METHYL-D-ASPARTATE; RECEPTOR; HIPPOCAMPUS;

D O I：

10.1016/0006-8993(93)91007-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of the stable adenosine analogue 2-chloroadenosine (CADO) on the component of the field excitatory postsynaptic potential (fepsp) mediated by the N-methyl-D-aspartate (NMDA) type of glutamate receptor was studied in the hippocampal CA1 area of the rat. CADO inhibited the NMDA receptor-mediated component of the fepsp (EC50 = 0.10 +/- 0.02 muM), more efficiently than it inhibited the fepsp (EC50 = 0.40 +/- 0.08 muM). The results suggest that adenosine may modulate phenomena associated with the NMDA receptor, such as synaptic plasticity and excitotoxicity.

引用

页码：351 / 356

页数：6

共 18 条

[1] POTENTIAL THERAPEUTIC USES OF N-METHYL-D-ASPARTATE ANTAGONISTS IN CEREBRAL-ISCHEMIA [J].

ALBERS, GW .

CLINICAL NEUROPHARMACOLOGY, 1990, 13 (03) :177-197

[2] ADENOSINE DEPRESSES INDUCTION OF LTP AT THE MOSSY FIBER-CA3 SYNAPSE INVITRO [J].

ALZHEIMER, C ;

ROHRENBECK, J ;

TENBRUGGENCATE, G .

BRAIN RESEARCH, 1991, 543 (01) :163-165

[3] THE EFFECTS OF ADENOSINE ON THE DEVELOPMENT OF LONG-TERM POTENTIATION [J].

ARAI, A ;

KESSLER, M ;

LYNCH, G .

NEUROSCIENCE LETTERS, 1990, 119 (01) :41-44

[4] INTERACTIONS OF ADENOSINE AND MAGNESIUM ON RAT HIPPOCAMPAL SLICES [J].

BARTRUP, JT ;

STONE, TW .

BRAIN RESEARCH, 1988, 463 (02) :374-379

[5] LONG-TERM POTENTIATION OF NMDA RECEPTOR-MEDIATED SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS [J].

BASHIR, ZI ;

ALFORD, S ;

DAVIES, SN ;

RANDALL, AD ;

COLLINGRIDGE, GL .

NATURE, 1991, 349 (6305) :156-158

[6] REGULATION OF GLUTAMATE AND ASPARTATE RELEASE FROM SLICES OF THE HIPPOCAMPAL CA1 AREA - EFFECTS OF ADENOSINE AND BACLOFEN [J].

BURKE, SP ;

NADLER, JV .

JOURNAL OF NEUROCHEMISTRY, 1988, 51 (05) :1541-1551

[7]

Collingridge G. L., 1989, HIPPOCAMPUS NEW VIST, P329

[8]

COLLINGRIDGE GL, 1988, J PHYSIOL-LONDON, V399, P283

[9] EXCITATORY AMINO-ACIDS IN SYNAPTIC TRANSMISSION IN THE SCHAFFER COLLATERAL COMMISSURAL PATHWAY OF THE RAT HIPPOCAMPUS [J].

COLLINGRIDGE, GL ;

KEHL, SJ ;

MCLENNAN, H .

JOURNAL OF PHYSIOLOGY-LONDON, 1983, 334 (JAN) :33-46

[10] GABA-B AUTORECEPTORS REGULATE THE INDUCTION OF LTP [J].

DAVIES, CH ;

STARKEY, SJ ;

POZZA, MF ;

COLLINGRIDGE, GL .

NATURE, 1991, 349 (6310) :609-611

← 1 2 →