TRITIATION OF ORGANIC-COMPOUNDS BY POLYMER-SUPPORTED ACID CATALYSTS

被引：17

作者：

BREWER, JR

JONES, JR

LAWRIE, KWM

SAUNDERS, D

SIMMONDS, A

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND

[2] AMERSHAM INT PLC,FOREST FARM,CARDIFF CF4 7YT,S GLAM,WALES

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1994年 / 34卷 / 04期

关键词：

POLYMER SUPPORTED ACID CATALYST; HYDROGEN ISOTOPE EXCHANGE; TRITIATION; ION EXCHANGE RESINS; NAFION;

D O I：

10.1002/jlcr.2580340411

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A range of organic compounds have been tritiated (and in some cases deuteriated) via hydrogen isotope exchange reactions using polymer supported acid catalysts. The extent and regiospecificity of labeling were investigated as a function of substrate and catalyst type. Although all the catalysts were found to be active in the tritiation of both aromatic and heterocyclic compounds, there was clear evidence that the extent of hydrogen isotope exchange was influenced by the nature of the polymer support matrix.

引用

页码：391 / 400

页数：10

共 14 条

[1] MECHANISM OF ELECTROPHILIC SUBSTITUTION OF HETEROAROMATIC COMPOUNDS .X. ACID-CATALYSED HYDROGEN EXCHANGE AT ALPHA- BETA- AND GAMMA-POSITIONS OF SUBSTITUTED PYRIDINE 1-OXIDES [J].