INTERACTION OF PDGF AND NATRIURETIC PEPTIDES ON MESANGIAL CELL-PROLIFERATION AND ENDOTHELIN SECRETION

被引:35
作者
KOHNO, M
IKEDA, M
JOHCHI, M
HORIO, T
YASUNARI, K
KURIHARA, N
TAKEDA, T
机构
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 265卷 / 05期
关键词
ATRIAL NATRIURETIC PEPTIDE; BRAIN NATRIURETIC PEPTIDE; PLATELET-DERIVED GROWTH FACTOR; PROTEIN KINASE-C; GUANOSINE; 3'; 5'-CYCLIC MONOPHOSPHATE;
D O I
10.1152/ajpendo.1993.265.5.E673
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The present study examined the possible interaction of platelet-derived growth factor (PDGF) and atrial or brain natriuretic peptides (ANP and BNP, respectively) on cellular proliferation and secretion of endothelin-1 in cultured rat mesangial cells. PDGF increased cellular proliferation and endothelin-1 secretion. The protein kinase C (PKC) inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, staurosporine, and PKC inhibitor peptide, inhibited such stimulation. Rat ANP-(1-28) and rat BNP-45 exhibited clearly dose-related inhibition of PDGF-stimulated cellular proliferation and endothelin-1 secretion. This inhibition by ANP and BNP was paralleled by an increase in the cellular level of guanosine 3',5'-cyclic monophosphate (cGMP). Results indicate that PDGF stimulates cellular proliferation and endothelin-1 secretion in cultured rat mesangial cells by a mechanism probably involving activation of PKC and that ANP and BNP inhibit such stimulation through a cGMP-dependent process.
引用
收藏
页码:E673 / E679
页数:7
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