ECTOPIC TRANSCRIPTION OF THE PARATHYROID-HORMONE GENE IN LYMPHOCYTES, LYMPHOBLASTOID-CELLS AND TUMOR-TISSUE

被引：2

作者：

HANDT, O ^{[1
]}

REIS, A ^{[1
]}

SCHMIDTKE, J ^{[1
]}

机构：

[1] FREE UNIV BERLIN, INST HUMAN GENET, W-1000 BERLIN 19, GERMANY

来源：

JOURNAL OF ENDOCRINOLOGY | 1992年 / 135卷 / 02期

关键词：

D O I：

10.1677/joe.0.1350249

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Using reverse transcription polymerase chain reaction, steady-state levels of parathyroid hormone (PTH) mRNA were investigated in a number of human, bovine and rat tissues. Transcripts were consistently detected in parathyroid glands as well as in lymphocytes, lymphoblastoid cells and several tumours. Levels of transcription were not measurably increased in lymphoblastoid cells and tumour tissues compared with unstimulated peripheral lymphocytes. The level of 'ectopic' transcription of the PTH gene in lymphoblastoid cells appeared to be resistant to the administration of both vitamin D and phorbol esters.

引用

页码：249 / 256

页数：8

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