ALCOHOL-CONSUMPTION AND ALCOHOL PHARMACOKINETICS - INTERACTIONS WITHIN THE NORMAL POPULATION

被引：36

作者：

WHITFIELD, JB ^{[1
]}

MARTIN, NG ^{[1
]}

机构：

[1] QUEENSLAND INST MED RES,BRISBANE,QLD 4006,AUSTRALIA

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1994年 / 18卷 / 02期

关键词：

ABSTINENCE; METABOLIC RATE; PEAK BAC; TWINS;

D O I：

10.1111/j.1530-0277.1994.tb00007.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

We have analyzed the interrelationships between habitual alcohol consumption, peak blood alcohol concentration after a standard dose, and rate of alcohol metabolism in a group of 199 male and 213 female twins. Both peak concentration and rate of metabolism are strongly associated with alcohol consumption levels, even in the range of 0-10 g of alcohol/day. The peak concentration and rate of metabolism were strongly correlated in both men and women; this is not due to their common dependence on alcohol intake nor to experimental error. These results show that the threshold for effects of habitual consumption on alcohol pharmacokinetics is much lower than previously suspected, and that there are factors that reduce preabsorptive or first-pass metabolism but increase postabsorptive metabolism.

引用

页码：238 / 243

页数：6

共 18 条

[1] KINETIC AND ELECTROPHORETIC PROPERTIES OF NATIVE AND RECOMBINED ISOENZYMES OF HUMAN-LIVER ALCOHOL-DEHYDROGENASE [J].