KETAMINE IN THE TREATMENT OF BRONCHOSPASM DURING MECHANICAL VENTILATION

被引：30

作者：

HEMMINGSEN, C

NIELSEN, PK

ODORICO, J

机构：

[1] Department of Anesthesiology, University of Copenhagen

[2] Medical Department P, Rigshospitalet, University of Copenhagen

来源：

AMERICAN JOURNAL OF EMERGENCY MEDICINE | 1994年 / 12卷 / 04期

关键词：

ASTHMA BRONCHOSPASM; BRONCHOLYTIC; KETAMINE; MECHANICAL VENTILATION;

D O I：

10.1016/0735-6757(94)90051-5

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

The effect of ketamine on bronchospasm during mechanical ventilation was evaluated in a prospective, placebo-controlled, double-blind trial. Fourteen mechanically ventilated patients with bronchospasm were randomly allocated to either ketamine 1 mg/kg or saline placebo. In the ketamine-treated patients, PO increased from 10.5 (±0.5) kPa to 16.4 (±2.7) kPa (P < .05), whereas PO in the placebo-treated patients remained unchanged. The PCO was constant in the ketamine group, although it increased from 5.6 (±0.9) kPa to 6.1 (±0.9) kPa in the placebo group (P < .05). The pulmonary stethoscopic bronchospasm improved immediately after the administration of ketamine, whereas the thoracic compliance remained unchanged. In conclusion, the ketamine-treated patients showed an improvement by stethoscopic examination, in PO and in PCO, suggesting that ketamine might be useful in the treatment of bronchospasm during mechanical ventilation. However, further studies are required to decide whether ketamine should be considered the drug of choice in patients with severe bronchospasm during ventilator treatment. © 1994.

引用

页码：417 / 420

页数：4

共 21 条

[1]

Lundy, Gowdy, Colboun, TRACHEAL SMOOTH MUSCLE RELAXANT EFFECT OF KETAMINE, BJA: British Journal of Anaesthesia, 46, pp. 333-336, (1974)

[2]

Wanna, Gergis, Procaine, Lidocaine, and Ketamine Inhibit Histamine-lnduced Contracture of Guinea Pig Tracheal Muscle in Vitro, Anesthesia & Analgesia, 57, pp. 25-27, (1978)

[3]

Gateau, Bourgain, Gaudy, Et al., EFFECTS OF KETAMINE ON ISOLATED HUMAN BRONCHIAL PREPARATIONS, BJA: British Journal of Anaesthesia, 63, pp. 692-695, (1989)

[4]

Nedergaard, Cocaine-like effect of ketamine on vascular adrenergic neurones, European Journal of Pharmacology, 23, pp. 153-161, (1973)

[5]

Corssen, Gutierrez, Reves, Et al., Ketamine in the anesthetic management of asthmatic patients., Anesth Analg, 51, pp. 588-594, (1972)

[6]

Shulman, Bar-Yishay, Gofrey, Use of Etomidate for Elective Cardioversion, Anesthesiology, 67, pp. 656-662, (1988)

[7]

Betts, Parkin, Use of ketamine in an asthamatic child, Anesth Analg, 81, pp. 588-590, (1971)

[8]

Fisher, Ketamine hydrochloride in severe bronchospasm, Anaesthesia, 32, pp. 771-772, (1977)

[9]

Strube, Hallam, Ketamine by continuous infusion in status asthmaticus, Anaesthesia, 41, pp. 1017-1019, (1986)

[10]

Rock, Rocha, L'Hommedieu, Et al., Use of ketamine in asthmatic children to treat respiratory failure refractory to conventional therapy, Critical Care Medicine, 14, pp. 514-516, (1986)

← 1 2 3 →