ENHANCED PRODUCTION OF HYDROXYL RADICALS BY THE XANTHINE-XANTHINE OXIDASE REACTION IN THE PRESENCE OF LACTOFERRIN

被引：77

作者：

BANNISTER, JV

BANNISTER, WH

HILL, HAO

THORNALLEY, PJ

机构：

[1] UNIV OXFORD, DEPT INORGAN CHEM, OXFORD OX1 3QR, ENGLAND

[2] UNIV OXFORD, RADCLIFFE INFIRM, NUFFIELD DEPT CLIN BIOCHEM, OXFORD OX2 6HE, ENGLAND

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1982年 / 715卷 / 01期

关键词：

D O I：

10.1016/0304-4165(82)90056-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The generation of hydroxyl radicals by the xanthine-xanthine oxidase reaction is increased by Fe-saturated lactoferrin isolated from pig neutrophils. Hydroxy radical production, measured by EPR spin trapping and by ethylene production from .alpha.-keto-.gamma.-methiol butyric acid, is produced by a Fenton-type Haber-Weiss reaction catalyzed by lactoferrin. The possibility that lactoferrin catalyzes such a reaction in vivo is considered.

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页码：116 / 120

页数：5

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