INTERACTION OF OPIOID MOLECULES WITH PS, PC AND PS/PC MONOLAYERS

被引：4

作者：

ALSINA, MA ^{[1
]}

MESTRES, C ^{[1
]}

VALENCIA, G ^{[1
]}

ANTON, JMG ^{[1
]}

REIG, F ^{[1
]}

机构：

[1] CSIC,CTR INVEST & DESARROLLO,PEPTIDE LAB,BARCELONA,SPAIN

来源：

COLLOID AND POLYMER SCIENCE | 1988年 / 266卷 / 09期

关键词：

Biochemistry - Biological Materials - Thin Films - Lipids;

D O I：

10.1007/BF01417867

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The interaction between opiate molecules and phosphatidylserine (PS) or phosphatidylcholine (PC) has been studied on compresion isotherms and penetration kinetics. Phosphatidylcholine-opiate interactions are weak and similar in magnitude for all opiate molecules. On contrary, PS and PS/PC interact strongly and differently with opiate molecules. The differences in penetration are not directly related to the pKa or hydrophobicity of the molecules.

引用

页码：832 / 835

页数：4

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