SOME EPINEPHRINE ANALOGS

被引：22

作者：

BERGMANN, ED

GOLDSCHM.Z

机构：

[1] Department of Organic Chemistry, Hebrew University, Jerusalem

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1968年 / 11卷 / 06期

关键词：

D O I：

10.1021/jm00312a004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of epinephrine analogs and corresponding 1-aryl-2-alkylaminoethyl chloride hydrochlorides and bromide hydrobromides have been prepared. The central intermediates of the syntheses were the 5-aryl-3-alkyl-2-oxazolidones (IV), accessible by alkylation of the product obtained using the Reformatzky reaction of an aromatic aldehyde with ethyl bromoacetate. The results of a pharmacological study of the products obtained are summarized. © 1968, American Chemical Society. All rights reserved.

引用

页码：1121 / &

共 38 条

[1]

ANGYAL SJ, 1963, ORGANIC SYNTHESES, V1, P690

[2]

BASTIAN JW, 1958, FED PROC, V17, P1367

[3] STEREOCHEMISTRY OF ADRENERGIC RECEPTORS - NEWER CONCEPTS ON MOLECULAR MECHANISM OF ACTION OF CATECHOLAMINES AND ANTIADRENERGIC DRUGS AT RECEPTOR LEVEL [J].