DEXAMETHASONE AND HYPERTENSION IN PRETERM INFANTS

被引:21
作者
GREENOUGH, A
EMERY, EF
GAMSU, HR
机构
[1] Department of Child Health, King's College Hospital, London
关键词
HYPERTENSION; CHRONIC LUNG DISEASE; DEXAMETHASONE; PRETERM DELIVERY;
D O I
10.1007/BF01958959
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
The magnitude and duration of the effect of dexamethasone on systolic blood pressure has been examined in 13 very preterm infants (median gestational age 25 weeks). All had chronic lung disease (CLD). To exclude any effect of CLD on blood pressure each infant acted as his or her own control. Systolic blood pressure increased in all infants (P < 0.01) and remained elevated for at least 48 h following cessation of therapy. The median maximum increase in blood pressure was 24 mm Hg (range 13-49 mmHg) and occurred on day 4 (median, range 2-10) of treatment. One infant developed hypertensive encephalopathy. These results demonstrate the need to monitor infants with CLD throughout steroid therapy and preferably for some days after it has ceased.
引用
收藏
页码:134 / 135
页数:2
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