CONGLOBATIN, A NOVEL MACROLIDE DILACTONE FROM STREPTOMYCES-CONGLOBATUS ATCC 31005

被引：43

作者：

WESTLEY, JW

LIU, CM

EVANS, RH

BLOUNT, JF

机构：

[1] Chemical Research Department, Hoffmann-La Roche Inc., Nutley

来源：

JOURNAL OF ANTIBIOTICS | 1979年 / 32卷 / 09期

关键词：

D O I：

10.7164/antibiotics.32.874

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Fermentation of deposited cultures of Streptomyces conglobatus, known to produce the polyether antibiotic, ionomycin has resulted in the isolation and characterization of a second metabolite, conglobatin (C28H38N2O6). X-Ray analysis revealed a dimeric macrolide dilactone structure for conglobatin, similar to the structures of the mold metabolites vermiculin and pyrenophorin, from which the absolute configuration of conglobatin has been inferred. The dimer consists of two molecules of 7-hydroxy-8-oxazoyl-2,4,6-trimethyl-2-octenoic acid joined by two ester linkages. © 1979, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：874 / 878

页数：5

共 11 条

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