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A MOLECULAR-MODEL OF MHC CLASS-I-RESTRICTED ANTIGEN PROCESSING

被引：467
作者：
MONACO, JJ
机构：
[1] Department of Microbiology and Immunology, Medical College of Virginia, Virginia Commonwealth University, Richmond
来源：
IMMUNOLOGY TODAY | 1992年 / 13卷 / 05期
关键词：
D O I：
10.1016/0167-5699(92)90122-N
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cells of higher vertebrates have evolved mechanisms that allow a sample of their intracellular contents to be available for surveillance by the immune system. This display of intracellular material is in the form of peptides bound to cell surface major histocompatibility complex (MHC) class I molecules. In this review, John Monaco presents a model of the mechanisms by which this takes place, based on the recent identification of a number of new genes in the MHC.
引用
收藏
页码：173 / 178
页数：6
相关论文
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