HUMAN CORTICOTROPIN-RELEASING HORMONE (HCRH) TEST - SEX AND AGE-DIFFERENCES IN PLASMA ACTH AND CORTISOL RESPONSES AND THEIR REPRODUCIBILITY IN HEALTHY-ADULTS

被引：22

作者：

TANAKA, K

SHIMIZU, N

IMURA, H

FUKATA, J

HIBI, I

TANAKA, T

NAKAGAWA, S

FUJIEDA, K

TAKEBE, K

YOSHINAGA, K

TAKAKURA, K

SUWA, S

TACHIBANA, K

KATO, K

YOSHIMI, T

MIURA, K

KUWAYAMA, A

OTA, Z

KATO, Y

SAITO, S

TAKAHARA, J

HASHIMOTO, K

NAWATA, H

MATSUKURA, S

YANAIHARA, N

机构：

[1] KYOTO UNIV, FAC MED, DEPT MED, DIV 2, KYOTO, KYOTO 606, JAPAN

[2] NATL CHILDRENS HOSP, DIV ENDOCRINOL & METAB, ENDOCRINE RES LAB, TOKYO, TOKYO 154, JAPAN

[3] HOKKAIDO UNIV, SCH MED, DEPT MED 2, SAPPORO, HOKKAIDO 060, JAPAN

[4] HOKKAIDO UNIV, SCH MED, DEPT PEDIAT, SAPPORO, HOKKAIDO 060, JAPAN

[5] HIROSAKI UNIV, SCH MED, DEPT INTERNAL MED 3, HIROSAKI, AOMORI 036, JAPAN

[6] TOHOKU UNIV, SCH MED, DEPT INTERNAL MED 2, SENDAI, MIYAGI 980, JAPAN

[7] UNIV TOKYO, FAC MED, DEPT NEUROSURG, TOKYO, TOKYO 113, JAPAN

[8] KANAGAWA CHILDRENS MED CTR, DEPT ENDOCRINOL & METAB, YOKOHAMA, KANAGAWA 231, JAPAN

[9] YAMANASHI MED COLL, DEPT PEDIAT, TAMAHO, YAMANASHI, JAPAN

[10] HAMAMATSU UNIV SCH MED, DEPT INTERNAL MED 2, HAMAMATSU, SHIZUOKA 43131, JAPAN

[11] GIFU UNIV, SCH MED, DEPT INTERNAL MED 3, GIFU 500, JAPAN

[12] NAGOYA NATL HOSP, DEPT NEUROSURG 1, NAGOYA, AICHI 460, JAPAN

[13] OKAYAMA UNIV, SCH MED, DEPT INTERNAL MED 3, OKAYAMA 700, JAPAN

[14] SHIMANE MED UNIV, DEPT MED, DIV 1, IZUMO, SHIMANE 693, JAPAN

[15] UNIV TOKUSHIMA, SCH MED, DEPT INTERNAL MED 1, TOKUSHIMA 770, JAPAN

[16] KAGAWA MED SCH, DEPT INTERNAL MED 1, MIKI, KAGAWA 76107, JAPAN

[17] KOCHI MED SCH, DEPT INTERNAL MED 2, KOCHI, KOCHI 783, JAPAN

[18] KYUSHU UNIV, FAC MED, DEPT INTERNAL MED 3, FUKUOKA 812, JAPAN

[19] MIYAZAKI MED COLL, DEPT INTERNAL MED 3, MIYAZAKI, MIYAZAKI 88916, JAPAN

[20] UNIV SHIZUOKA, DEPT PHARMACEUT SCI, SHIZUOKA, SHIZUOKA 442, JAPAN

来源：

ENDOCRINE JOURNAL | 1993年 / 40卷 / 05期

关键词：

HCRH; ACTH; HYPOTHALMIC-PITUITARY-ADRENOCORTICAL SYSTEM; DIAGNOSTIC DRUG;

D O I：

10.1507/endocrj.40.571

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effectiveness and safety of MCI-028, a synthetic human corticotropin-releasing hormone (hCRH), as a diagnostic drug were examined in 65 healthy male and 24 healthy female adult volunteers. Mean maximum concentrations of plasma ACTH and cortisol after intraveneous administration of 100 mu g of MCI-028 were 3.0 and 2.0 times their basal concentrations, respectively, and there were no significant age or sex differences in the responses. Good reproducibility was observed in the responses in 59 male subjects who received a second administration after 1 to 2 weeks. Although slight adverse reactions such as mild and transient hot flushing were observed, these were not serious.

引用

页码：571 / 579

页数：9

共 13 条

[1]

FUKATA J, 1988, ENDOCRINOL JAPON, V35, P491

[2] EFFECT OF SYNTHETIC OVINE CORTICOTROPIN-RELEASING FACTOR - DOSE-RESPONSE OF PLASMA ADRENOCORTICOTROPIN AND CORTISOL [J].